BCAAs

What are BCAAs?

BCAA is the acronym for Branched-Chain Amino Acids and refers to three amino acids with a "branched-chain" chemical structure: leucine, valine, and isoleucine. They are all essential amino acids, which means the body cannot synthesise them and they must be obtained through diet or food supplements.

Scientific studies report that BCAAs:

  • Are essential for protein synthesis in humans
  • Support muscle growth and recovery
  • Contribute to energy metabolism during exercise

References

Rubio J et al., 2007. Aqueous and hydroalcoholic extracts of Black Maca (Lepidium meyenii) improve scopolamine-induced memory impairment in mice. Food Chem Toxicol, 45(10): 1882-90.

Stone M et al., 2009. A pilot investigation into the effect of maca supplementation on physical activity and sexual desire in sportsmen. J Ethnopharmacol, 126(3): 574-6.

Gonzales GF et al., 2014. Maca (Lepidium meyenii Walp), a review of its biological properties. Rev Peru Med Exp Salud Publica, 31(1): 100-10.

Gonzales GF et al., 2002. Effect of Lepidium meyenii (Maca) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men. Andrologia, 34(6): 367-72.

Zenico T et al., 2009. Subjective effects of Lepidium meyenii (Maca) extract on well-being and sexual performances in patients with mild erectile dysfunction: a randomised, double-blind clinical trial. Andrologia, 41(2): 95-9.

Gonzales GF et al., 2008. Antagonist effect of Lepidium meyenii (red maca) on prostatic hyperplasia in adult mice. Andrologia, 40(3): 179-85.

Brooks NA et al., 2008. Beneficial effects of Lepidium meyenii (Maca) on psychological symptoms and measures of sexual dysfunction in postmenopausal women are not related to estrogen or androgen content. Menopause, 15(6):1157-62.

Meissner HO et al., 2006. Therapeutic effects or pre-gelatinized Maca (Lepidium Peruvianum Chacon) used as a non-hormonal alternative to HRT in perimenopausal women - clinical pilot study. Int J Biomed Sci, 2: 143-159.

Meissner HO et al., 2005. Use of gelatinized Maca (Lepidium peruvianum) in early postmenopausal women. Int J Biomed Sci, 1(1): 33-45.

Bhaaskar S, Shalini V, Helen A. 2011. Quercetin regulates oxidized LDL induced inflammatory changes in human PBMCs by modulating the TLR-NF-kB signaling pathway. Immunobiology, 216(3): 367-73.

Derlindati E et al., 2012. Quercetin-3-O-glucuronide affects the gene expression profile of M1 and M2a human macrophages exhibiting anti-inflammatory effects. Food Funct. 3(11): 1144-52.

Nickel T, et al. 2011. Immunoregulatory effects of the flavonol quercetin in vitro and in vivo. Eur J Nutr. 50(3): 163-72.

Cavalcanti E et al., 2014. Administration of reconstituted polyphenol oil bodies efficiently suppresses dendritic cell inflammatory pathways and acute intestinal inflammation. PLoS One. 9(2): e88898.

Jiménez-Aliaga K et al., 2011. Quercetin and rutin exhibit antiamyloidogenic and fibril-disaggregating effects in vitro and potent antioxidant activity in APPswe cells. Life Sci. 89(25-26): 939-45.

Yu ES et al., 2008. Regulatory mechanisms of IL-2 and IFNgamma suppression by quercetin in T helper cells. Biochem Pharmacol. 76(1): 70-8.

Park HJ et al., 2011. Quercetin regulates Th1/Th2 balance in a murine model of asthma. Int Immunopharmacol. 9(3): 261-7.

Terasawa N, Okamoto K, Nakada K, Masuda K, Effect of Conjugated Linoleic Acid Intake on Endurance Exercise Performance and Anti-fatigue in Student Athletes, J Oleo Sci. 2017 Jul 1;66(7):723-733. doi: 10.5650/jos.ess17053

Whigham LD, Watras AC, Schoeller DA. Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans, Am J Clin Nutr. 2007 May;85(5):1203-11. doi: 10.1093/ajcn/85.5.1203

Gaullier JM et al. Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans, Am J Clin Nutr. 2004 Jun;79(6):1118-25. doi: 10.1093/ajcn/79.6.1118

Belitz H.D. et al. (2009). Food Chemistry "1 Amino Acids, Peptides, Proteins", 4th revised and extended Edition, 8-9.

Moro T et al. Amino Acid Sensing in Skeletal Muscle, Trends Endocrinol Metab. 2016 Nov;27(11):796-806. doi: 10.1016/j.tem.2016.06.010.

Belitz, H.D. et al. (2009). Food Chemistry "3 Lipids", 4th revised and extended Edition, 215

Teixeira, A. et al. (2014). Natural Bioactive Compounds from Winery By-Products as Health Promoters: A Review. International Journal of Molecular Sciences, 15: 15638-15678

Corrochano A. R. et al. (2018). Invited review: Whey proteins as antioxidants and promoters of cellular antioxidant pathways. Journal of Dairy Science, 101: 4747–4761

Schneider JY et al. Effects of chronic oral L-arginine administration on the L-arginine/NO pathway in patients with peripheral arterial occlusive disease or coronary artery disease: L-Arginine prevents renal loss of nitrite, the major NO reservoir. Amino Acids. 2015 Sep;47(9):1961-74. doi: 10.1007/s00726-015-2031-0

Wang R. Et al. L-Arginine Enhances Protein Synthesis by Phosphorylating mTOR (Thr 2446) in a Nitric Oxide-Dependent Manner in C2C12 Cells. Oxid Med Cell Longev. 2018 Apr 26;2018:7569127. doi. 10.1155/2018/7569127

Melik Z. Et al. L-arginine as dietary supplement for improving microvascular function. Clin Hemorheol Microcirc. 2017;65(3):205-217. doi: 10.3233/CH-16159

McNeal CJ et al. Safety and Effectiveness of Arginine in Adults. J Nutr. 2016 Dec;146(12):2587S-2593S. doi: 10.3945/jn.116.234740

McNeal CJ et al. Safety of dietary supplementation with arginine in adult humans. Amino Acids. 2018 Jun 1. doi: 10.1007/s00726-018-2594-7

Berg J.M., Tymoczko J.L, Stryer L. Biochemistry. 5th edition. New York: W H Freeman; 2002

Mangano KM et al, Dietary protein is associated with musculoskeletal health independently of dietary pattern: the Framingham Third Generation Study. Am J Clin Nutr. 2017 Mar;105(3):714-722. doi: 10.3945/ajcn.116.136762

Ministero della Salute (March, 2018). Altri Nutrienti e Altre Sostanze ad Effetto Nutritivo o Fisiologico

Shimomura, Y. and Kitaura, Y. (2018). Physiological and pathological roles of branched-chain amino acids in theregulation of protein and energy metabolism and neurological functions. Pharmacological Research 133: 215-217

Sung, D. J. et al. (2016). Role of l-carnitine in sports performance: Focus on ergogenic aid and antioxidant. Science & Sports 31: 177-188.

Dulloo AG. et al. Normal caffeine consumption: influence on thermogenesis and daily energy expenditure in lean and postobese human volunteers. The American Journal of Clinical Nutrition. 1989;49(1):44-50. doi:10.1093/ajcn/49.1.44.

Dulloo AG. et al. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. The American Journal of Clinical Nutrition. 1999;70(6):1040-1045. doi:10.1093/ajcn/70.6.1040

Hoffman J. et al. Thermogenic effect of an acute ingestion of a weight loss supplement. Journal of the International Society of Sports Nutrition. 2008;5(Suppl 1). doi:10.1186/1550-2783-5-s1-p7

Hursel R. et al. The effects of catechin rich teas and caffeine on energy expenditure and fat oxidation: a meta-analysis. Obesity Reviews. 2011;12(7). doi:10.1111/j.1467-789x.2011.00862.x

Outlaw J. et al. Effects of ingestion of a commercially available thermogenic dietary supplement on resting energy expenditure, mood state and cardiovascular measures. Journal of the International Society of Sports Nutrition. 2013;10(1):25. doi:10.1186/1550-2783-10-25

Steensels S. et al. Fatty acid activation in thermogenic adipose tissue. BBA - Molecular and Cell Biology of Lipids. 2019;79-90. doi:10.1016/j.bbalip.2018.05.008

Stohs S. J. et al. A Review of Natural Stimulant and Non-stimulant Thermogenic Agents. Phytotherapy Research. 2016;30: 732-740. doi:10.1002/ptr.5583

EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to oat and barley grain fibre and increase in faecal bulk (ID 819, 822) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA Journal 2011;9(6):2249. [13 pp.]. doi:10.2903/j.efsa.2011.2249.

EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to oat beta-glucan and lowering blood cholesterol and reduced risk of (coronary) heart disease pursuant to Article 14 of Regulation (EC) No 1924/2006. EFSA Journal 2010;8(12):1885. [15 pp.] doi:10.2903/j.efsa.2010.1885.

EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to beta-glucans from oats and barley and maintenance of normal blood LDL-cholesterol concentrations (ID 1236, 1299), increase in satiety leading to a reduction in energy intake (ID 851, 852), reduction of post-prandial glycaemic responses (ID 821, 824), and “digestive function” (ID 850) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA Journal 2011;9(6):2207. [21 pp.]. doi:10.2903/j.efsa.2011.2207.

EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2013. Scientific Opinion on the substantiation of a health claim related to glycaemic carbohydrates and recovery of normal muscle function (contraction) after strenuous exercise pursuant to Article 13(5) of Regulation (EC) No 1924/2006. EFSA Journal 2013;11(10):3409, 10 pp. doi:10.2903/j.efsa.2013.3409.

Fritz RD et al. Oat safety for celiac disease patients: theoretical analysis correlates adverse symptoms in clinical studies to contaminated study oats. Nutrition Research. 2018;60:54-67. doi:10.1016/j.nutres.2018.09.003.

Hareland G.A et al. Oats. in Encyclopedia of Food Sciences and Nutrition (Second Edition). Amsterdam: Academic Press; 2003: 4213-4220.

Hall JE. Guyton and Hall Textbook of Medical Physiology. 11th ed. Elsevier; 2016.

Launay A. Pharmacognosie, phytochimie, plantes médicinales — cinquième édition J. Bruneton, Éditions Lavoisier Tec & Doc, 2016.

Ministerio della Salute - Decreto 9 luglio 2012 - Disciplina dell’impiego negli integratori alimentari di sostanze e preparati vegetali (G.U. 21-7-2012 serie generale n. 169)

Widmaier EP et al. Human Physiology: the Mechanisms of Body Function. 9th ed. New York, NY: McGraw-Hill; 2003.

Bendtsen LQ et al. Effect of Dairy Proteins on Appetite, Energy Expenditure, Body Weight, and Composition: a Review of the Evidence from Controlled Clinical Trials. Advances in Nutrition. 2013;4(4):418-438. doi:10.3945/an.113.003723.

Mcgregor RA & Poppitt SD. Milk protein for improved metabolic health: a review of the evidence. Nutrition & Metabolism. 2013;10(1):46. doi:10.1186/1743-7075-10-46.

Churchward-Venne T.A. et al, Supplementation of a suboptimal protein dose with leucine or essential amino acids: effects on myofibrillar protein synthesis at rest and following resistance exercise in men. The Journal of Physiology. 2012;590(11):2751-2765. doi:10.1113/jphysiol.2012.228833.

Devries MC, Phillips SM. Supplemental protein in support of muscle mass and health: advantage whey. Journal of Food Science. 2015;80(S1). doi:10.1111/1750-3841.12802.

Garrido, B.C. et al., Proteomics in quality control: Whey protein-based supplements. Journal of Proteomics. 2016;147:48-55. doi:10.1016/j.jprot.2016.03.044.

Hulmi J.J. et al, Resistance exercise with whey protein ingestion affects mTOR signaling pathway and myostatin in men. Journal of Applied Physiology. 2009;106(5):1720-1729. doi:10.1152/japplphysiol.00087.2009.

Norton, L. E., et al., Leucine content of dietary proteins is a determinant of postprandial skeletal muscle protein synthesis in adult rats. Nutrition & Metabolism. 2012;9(1):67. doi:10.1186/1743-7075-9-67.

Pereira, C. G. et al., Characterization and detection of adulterated whey protein supplements using stationary and time-resolved fluorescence spectroscopy. Lwt. 2018;97:180-186. doi:10.1016/j.lwt.2018.06.050.

Anssi H Manninen, Protein hydrolysates in sports nutrition. Nutrition & Metabolism. 2009;6(1):38. doi:10.1186/1743-7075-6-38.

Brandelli, A. et al, Whey as a source of peptides with remarkable biological activities. Food Research International. 2015;73:149-161. doi:10.1016/j.foodres.2015.01.016.

Garrido, B.C. et al., Proteomics in quality control: Whey protein-based supplements. Journal of Proteomics. 2016;147:48-55. doi:10.1016/j.jprot.2016.03.044.

Norton, L. E., et al., Leucine content of dietary proteins is a determinant of postprandial skeletal muscle protein synthesis in adult rats. Nutrition & Metabolism. 2012;9(1):67. doi:10.1186/1743-7075-9-67.

Pereira, C. G. et al., Characterization and detection of adulterated whey protein supplements using stationary and time-resolved fluorescence spectroscopy. Lwt. 2018;97:180-186. doi:10.1016/j.lwt.2018.06.050.

Garrido, B.C. et al., Proteomics in quality control: Whey protein-based supplements. Journal of Proteomics. 2016;147:48-55. doi:10.1016/j.jprot.2016.03.044.

Norton, L. E., et al., Leucine content of dietary proteins is a determinant of postprandial skeletal muscle protein synthesis in adult rats. Nutrition & Metabolism. 2012;9(1):67. doi:10.1186/1743-7075-9-67.

Pereira, C. G. et al., Characterization and detection of adulterated whey protein supplements using stationary and time-resolved fluorescence spectroscopy. Lwt. 2018;97:180-186. doi:10.1016/j.lwt.2018.06.050.

Berg J.M., Tymoczko J.L, Stryer L. Biochemistry. 5th edition. New York: W. H. Freeman; 2002.

EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to protein and increase in satiety leading to a reduction in energy intake (ID 414, 616, 730), contribution to the maintenance or achievement of a normal body weight (ID 414, 616, 730), maintenance of normal bone (ID 416) and growth or maintenance of muscle mass (ID 415, 417, 593, 594, 595, 715) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA Journal 2010;8(10):1811. [ 24 pp.]. doi:10.2903/j.efsa.2010.1811.

Pasiakos, S. M. et al. The Effects of Protein Supplements on Muscle Mass, Strength, and Aerobic and Anaerobic Power in Healthy Adults: A Systematic Review. Sports Medicine. 2014;45(1):111-131. doi:10.1007/s40279-014-0242-2

Cooper, R. et al. Creatine supplementation with specific view to exercise/sports performance: an update. Journal of the International Society of Sports Nutrition. 2012;9(1):33. doi:10.1186/1550-2783-9-33

EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to creatine and increase in physical performance during short-term, high intensity, repeated exercise bouts (ID 739, 1520, 1521, 1522, 1523, 1525, 1526, 1531, 1532, 1533, 1534, 1922, 1923, 1924), increase in endurance capacity (ID 1527, 1535), and increase in endurance performance (ID 1521, 1963) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA Journal 2011;9(7):2303. [24 pp.]. doi:10.2903/j.efsa.2011.2303.

EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific opinion on creatine in combination with resistance training and improvement in muscle strength: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006. EFSA Journal 2016;14(2):4400, 17 pp. doi:10.2903/j.efsa.2016.4400

L. E. Heaton et al. Selected In-Season Nutritional Strategies to Enhance Recovery for Team Sport Athletes: A Practical Overview. Sports Medicine. 2017;47(11):2201-2218. doi:10.1007/s40279-017-0759-2

R.B. Kreider et al. International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. Journal of the International Society of Sports Nutrition. 2017;14(1). doi:10.1186/s12970-017-0173-z

Barbosa PO et al. Açai (Euterpe oleracea Mart.) pulp dietary intake improves cellular antioxidant enzymes and biomarkers of serum in healthy women. Nutrition. 2016;32(6):674-680. doi:10.1016/j.nut.2015.12.030

Schauss AG et al. Phytochemical and Nutrient Composition of the Freeze-Dried Amazonian Palm Berry, Euterpe oleraceae Mart. (Acai). Journal of Agricultural and Food Chemistry. 2006;54(22):8598-8603. doi:10.1021/jf060976g https://pubs.acs.org/doi/abs/10.1021/jf060976g

Yamaguchi KKL et al., Amazon acai: Chemistry and biological activities: A review. Food Chemistry. 2015;179:137-151. doi: 10.1016/j.foodchem.2015.01.055

Bruneton, J. Pharmacognosie: Phytochimie, plantes médicinales. 2nd ed. Paris: Lavoisier Éditeur scientifique, technique et médical; 1993

El-Kenawy AE-M. et al. Tumeric or Curcuma longa Linn. Nonvitamin and Nonmineral Nutritional Supplements. 2019:447-453. doi:10.1016/b978-0-12-812491-8.00059-x

Menon VP, Sudheer AR. Antioxidant And Anti-Inflammatory Properties Of Curcumin. Advances in Experimental Medicine and Biology. 2007:105-125. doi:10.1007/978-0-387-46401-5_3

Nair K. P. P., 12-Neutraceutical properties of Turmeric. In: The Agronomy and Economy of Turmeric and Ginger, The Invaluable Medicinal Spice Crops. Amsterdam: Elsevier; 2013: 179–204

Sarker MR, Franks SF. Efficacy of curcumin for age-associated cognitive decline: a narrative review of preclinical and clinical studies. GeroScience. 2018;40:73–95. doi.org/10.1007/s11357-018-0017-z

Sun J. et al. Role of curcumin in the management of pathological pain. Phytomedicine. 2018;48:129-140. doi:10.1016/j.phymed.2018.04.045

D. Fukushima. 6 - Soy proteins, Editor(s): R.Y. Yada, In Woodhead Publishing Series in Food Science, Technology and Nutrition, Proteins in Food Processing, Woodhead Publishing, 2004: 123-145. doi:10.1533/9781855738379.1.123

Hamilton-Reeves JM et al. Clinical studies show no effects of soy protein or isoflavones on reproductive hormones in men: results of a meta-analysis. Fertility and Sterility. 2010;94(3):997-1007. doi:10.1016/j.fertnstert.2009.04.038

Montgomery KS. Soy Protein. The Journal of Perinatal Education. 2003;12(3):42-45. doi:10.1891/1058-1243.12.3.42

Wildman, R.E.C., Handbook of Nutraceuticals and Functional Foods - Chapter 05 Soy Protein, Soybean Isoflavones, and Bone Health: A Review of the Animal and Human Data, 2001

Jenkins DJ et al. Soy Protein Reduces Serum Cholesterol by Both Intrinsic and Food Displacement Mechanisms. The Journal of Nutrition. 2010 Dec;140(12):2302S-2311S. doi: 10.3945/jn.110.124958

Michelfelder AJ, Soy: A Complete Source of Protein. American Family Physician. 2009;79(1):43-47

Mateos-Aparicio I et al. Soybean, a promising health source. Nutrición Hospitalaria. 2008;23(4):305-312

Paul G, Mendelson GJ, Evidence Supports the Use of Soy Protein to Promote Cardiometabolic Health and Muscle Development. Journal of the American College of Nutrition. 2015;34 Suppl 1:56-9. doi: 10.1080/07315724.2015.1080531

Phillips SM, Tang JE, Moore DR, The role of milk- and soy-based protein in support of muscle protein synthesis and muscle protein accretion in young and elderly persons. Journal of the American College of Nutrition. 2009 Aug;28(4):343-54

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